Post-operative Neurosurgery
Conditions
Keywords
Aerosol delivery, Invasive mechanical ventilation, Jet Nebulizer, Vibrating-Mesh nebulizer
Brief summary
Many devices are available for nebulising drug solution during invasive mechanical ventilation. Vibrating-mesh nebulizers ensure the highest lung deposition output. A recent international survey on aerosol therapy during mechanical ventilation (Ehrmann et al. 2013) reported that jet nebulizers remained the mostly used. The aim of this study is to compare lung deposition of a radiolabeled administered with both nebulizers during invasive mechanical ventilation by planar scintigraphy.
Interventions
Sponsors
Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* Invasive mechanical ventilation * Healthy lungs
Exclusion criteria
* Discontinued procedure due to adverse events.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pulmonary deposition | Immediately after nebulization by imaging assessment, an expected average of 30 minutes |
Secondary
| Measure | Time frame |
|---|---|
| Penetration index | Immediately after nebulization by imaging assessment, an expected average of 30 minutes |
| Mechanical ventilation settings | During nebulisation time, an expected average of 15 minutes |
| Lung function | Preoperative assessment, the day before inclusion |
Countries
Belgium
Outcome results
None listed