Pain, Postoperative
Conditions
Keywords
Ketamine, Magnesium, Analgesia, Liposuction, Lipoabdominoplasty, Preemptive analgesia
Brief summary
Lipoabdominoplasty and liposuction are one of the most common plastic surgeries. The management of postoperative pain is complex. Non Steroidal Anti Inflammatory Drugs (NSAIDs) are insufficient, while opioids are avoided by their adverse effects and regional techniques are hampered by a premature discharge. In this context, the investigators seek an intraoperative multimodal analgesic technique blocking NMDA receptors with ketamine plus magnesium to significantly decrease postoperative pain.
Interventions
DRUGSaline
50 mL syringe will be infused at 0.3 mL/Kg in bolus and then 0.15 mL/Kg/h 100 mL flask will be infused at 1mL/Kg in bolus for 30 min and then 0.25mL/Kg/h
DRUGKetamine
50 mL syringe will be infused at 0.3 mL/Kg in bolus and then 0.15 mL/Kg/h 100 mL flask will be infused at 1mL/Kg in bolus for 30 min and then 0.25mL/Kg/h
DRUGKetamine + magnesium
50 mL syringe will be infused at 0.3 mL/Kg in bolus and then 0.15 mL/Kg/h 100 mL flask will be infused at 1mL/Kg in bolus for 30 min and then 0.25mL/Kg/h
Sponsors
University of Chile
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Female and male * 18 years or older * Liposuction and lipoabdominoplasty * ASA 1 and 2 * BMI 21-28 Kg/m2 * Full secondary education
Exclusion criteria
* Patients with surgeries added to the main proceedings * Scheduled to tuck in Flor de Lis or Body Lift * History of use of analgesic drugs 48 hours before surgery * Peripheral central neurological diseases * Known allergy will be excluded to medication in use in this study (ketamine, magnesium, clindamycin and penicillin or other)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Opioids consumption | 12 h after surgery | — |
| Postoperative Pain (Postoperative Pain and Disability Scale) | 2, 7, 14, 21, 45 and 90 days after surgery | Postoperative Pain and Disability Scale (Body-PPDS) will be used to quantify pain |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Early postoperative pain (Time to first request for supplemental analgesia) | 1 day | Time to first request for supplemental analgesia. |
| Postoperative Chronic Pain (McGill scale) | Day after surgery, 7, 30 and 90 days after surgery | McGill scale for chronic painwill be used to quantify pain |
| Disability (Time delay in returning to work) | 90 days | Time delay in returning to work. |
| Early postoperative pain (Visual analogue pain scale) | 0, 2, 4, 6, 12 and 24 h after surgery | Visual analogue pain scale (0-10) will be used to quantify pain |
Other
| Measure | Time frame | Description |
|---|---|---|
| Drug Side Effect | First day after surgery | Hallucinations, unpleasent dreams or some patient discomfort, sedation level, pruritus, hypotension, bradycardia, urinary retention, nausea, vomiting. |
| Other Variables | First day | Sociodemographic variables; surgical variables as liters of aspirated fat, weight of resected flap, operative time, bleeding measured as the difference between pre and postoperative hemoblobinemia, immediate postoperative complications such as bleeding or hematoma and thromboembolic complications; anesthetic variables as total amount of remifentanil and sevorane consumption. |
Countries
Chile
Outcome results
None listed