Helicobacter Infections
Conditions
Keywords
Stomach Neoplasms, proton pump inhibitor, endoscopic submucosal dissection, Helicobacter pylori, Gastritis, Atrophic
Brief summary
The purpose of this study is to know the distribution of HP in stomach before use of PPI, during use of PPI, and after stop of PPI.
Detailed description
Endoscopy and biopsy will be performed to investigate the distrubition of HP before, during, and after using PPI.
Interventions
1. Pre ESD (endoscopic submucosal dissection) * Assessment atrophy and metaplasia in stomach, Check Helicobacter pylori * Use of PPI for 2 months 2. Post ESD 1 (After 2 months) * Assess the distribution of helicobacter pylori after using PPI. * Stop of PPI 3. Post ESD 2 (After 4 months) * Assess the distribution of helicobacter pylori after stop of PPI.
Sponsors
Asan Medical Center
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
19 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
1. Patients who are indicated to endoscopic resection due to gastric neoplasm 2. Aged between 19 to 65 years 3. Informed consent
Exclusion criteria
1. Previous history of HP eradication 2. Previous history of PPI use within 6 months 3. No HP infection
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Analysis the change of Helicobacter pylori distribution according to the use of proton pump inhibitor | Change in the distribution of Helicobacter Pylori(HP) at 4 months. |
Secondary
| Measure | Time frame |
|---|---|
| Analysis the change of HP distribution according to the use of PPI in atrophic change of stomach | Change in the distribution of Helicobacter Pylori(HP) at 4 months. |
Countries
South Korea
Outcome results
None listed