Magnet Resonance Imaging to Evaluate of Dynamic T2 Preparation Puls by Patients With Shunt or Chronic Obstructive Pulmonary Disease

Cardiac Magnet Resonance Imaging to Evaluate of Dynamic T2 Preparation Puls by Patient With Shunt or Patients With Chronic Obstructive Pulmonary Disease (COPD)

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02449083

Enrollment

Registered

2015-05-20

Start date

2014-06-30

Completion date

2015-08-31

Last updated

2015-11-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dynamic T2 Preparation

Keywords

MRI, Shunt, COPD, Dynamic T2 Preparation Puls, new sequences, magnet resonance imaging, ventricular septal defect, Atrial septal defect

Brief summary

There is preliminary evidence that a dynamic T2 Preparations Puls sequence by cardiac magnet resonance imaging can differentiate between oxygenated and deoxygenated blood. In adult patients with inborn heart defects this has not yet been researched. Therefore,patients with ventriculoperitoneal shunt, septal and atrio-septal shunt should be examined. Also, patients with chronic obstructive pulmonary disease should be examined. The aim of this study is the validation of a novel magnet resonance sequence in terms of a distinction of oxygenated blood to deoxygenated blood in comparison to invasive method of measuring cardiac catheterization.

Interventions

PROCEDUREMRI

MRI

PROCEDUREcoronary angiography

coronary angiography

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* patients with atrial septal defect (ASD) or ventricular septal defect (VSD) and COPD * written informed consent

Exclusion criteria

* patients with ST-elevation * contraindication for MRI * heavy kidney disease * pregnant or breast feeding women

Design outcomes

Primary

Measure	Time frame	Description
ventricular volumetry	baseline	ventricular volumetry by Cardiac Magnet Resonance Imaging using dynamic T2 Preparation Puls for arithmetical determination of end-systolic volume, end-diastolic volume, ejection fraction, stroke volume and myocardial weight

Secondary

Measure	Time frame	Description
oxygen partial pressure	baseline	Determination of oxygen partial pressure (pO2) during angiography
carbon dioxide partial pressure	baseline	Determination of carbon dioxide partial pressure (pCO2) during angiography
pH-value	baseline	Determination of pH-value od blood during angiography
Blood gas analysis	baseline	Determination of base excess of blood during angiography
Major adverse cardiac events	12 month after procedure	Major adverse cardiac events: death, new indication for angiography, hospitalization

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026