Overweight and Obesity
Conditions
Keywords
probiotics, Lactobacillus, obesity, body composition
Brief summary
The investigators aimed to study the effect of supplementation with species of Lactobacillus on anthropometric measurements, body composition, appetite and serum lipid profile in overweight and obese adults
Detailed description
The Objective of This Study was Evaluating the Effect of supplementation with Species of Lactobacillus on anthropometric measurements include weight, waist and hip circumference , body composition include body fat and muscle percent, appetite measured by visual analogues scale and serum lipid profile in overweight and obese adults.
Interventions
DIETARY_SUPPLEMENTSpecies of Lactobacillus
2 capsule a day Lactofem probiotics containing Species of Lactobacillus
DIETARY_SUPPLEMENTlactose
2 capsule a day containing lactose
Sponsors
Urmia University of Medical Sciences
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Age 18-65 years * BMI more than 25 Kg/m2
Exclusion criteria
* taking drugs that could affect weight change, including anti-diabetic drugs, lipid lowering drugs * endocrine,cardiovascular, thyroid, or chronic liver disease. * had received surgery to reduce weight * taking probiotics or antibiotics within one month * Pregnancy or lactation or menopause * A history of cancer * Heart disease - cardiovascular, pulmonary, renal and diabetes * A history of autoimmune disease * Taking certain medications such as blood pressure control, statins, insulin sensitivity enhancers * weight change over five percent within three months * change in activity or diet habit
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| weight change | Change from Baseline in body weight at 12 weeks |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| blood pressure | Baseline,12 weeks | include systolic and diastolic blood pressure |
| Anthropometric Measurement BMI | Baseline,4 weeks, 8 weeks, 12 weeks | Body Mass Index (BMI) kg/m2 |
| Anthropometric Measurement WC | Baseline,12 weeks | waist circumference (WC) measures by cm |
| Anthropometric Measurement HC | Baseline,12 weeks | hip circumference (HC) measures by cm |
| Appetite | Baseline,4 weeks, 8 weeks, 12 weeks | numeric analogue Scale (NAS) mm |
| defecation | Baseline,4 weeks, 8 weeks, 12 weeks | Bristol stool scale (BBS) |
| mid arm circumference Measurement | Baseline,12 weeks | — |
| Serum Lipid Profile | Baseline,12 weeks | — |
| skinfold thickness | Baseline,12 weeks | triceps, biceps, supra iliac and subscapular skinfold |
| body fat percent | Baseline,12 weeks | — |
| Anthropometric Measurement WHR | Baseline,12 weeks | waist to hip ratio (WHR) |
Countries
Iran
Outcome results
None listed