HES and Acute Kidney Injury in Adult Cardiac Surgery

The Association Between Hydroxyethyl Starch 130/0.4 and Acute Kidney Injury After Cardiopulmonary Bypass: a Single-center Retrospective Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02445820

Enrollment

697

Registered

2015-05-15

Start date

2014-11-30

Completion date

2015-07-31

Last updated

2015-10-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Kidney Injury After Adult Cardiac Surgery

Brief summary

This study retrospectively assess the effect or using balanced hydroxyethyl sctarch (HES) 130/0.4 or a balanced crystalloid solution as a pump prime and for intraoperative fluid therapy on the risk of early acute postoperative kidney injury in adult cardiac surgery patients.

Interventions

DRUGHES

2500 mL of balanced HES 130/0.4

DRUGCrystalloid

2500 mL of balanced crystalloid.

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Age ≥ 18 yo * Having on pump cardiac surgery at CHU of Liège between April 2013 and June 2014

Exclusion criteria

* Off pump surgery * Use of Blood or Albumin in the cardiopulmonary bypass priming solution * Preoperative dialysis

Design outcomes

Primary

Measure	Time frame	Description
AKIN SCr	Forty eight hours	Stage of acute kidney injury using the Acute Kidney Injury Network Classification omitting the diuresis criteria.

Secondary

Measure	Time frame	Description
Postoperative dialysis	30 days	Requirement of postoperative renal replacement therapy
Respiratory complication	30 days	Need for reintubation, non-invasive ventilation or prolonged intensive care unit stay as a consequence of atelectasis, pulmonary edema or pneumonia.
AKIN SCr+UO	Forty eight hours	Stage of acute kidney injury using the Acute Kidney Injury Network Classification including the diuresis criteria.
Hospital stay	30 days	Length of stay at the hospital
30-day mortality	30 days	Death in hospital or within 30 days of surgery
ICU stay	30 days	Length of stay at the intensive care unit

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026