Autistic Disorder
Conditions
Keywords
neurophysiology
Brief summary
This study aims to identify clinical and biological markers which would allow to evaluate precisely the evolution of children with autism spectrum disorders throughout intervention.
Detailed description
200 children with autism spectrum disorders (1-12 years old) will be included in a 2 years follow-up study. Both clinical and neurophysiological evaluations (electrophysiological and eye tracking) will be completed at different times of the follow-up. This integrative approach, combining clinical and biological markers, will allow the identification of different developmental trajectories and then a better individuation of treatment in autism spectrum disorders.
Interventions
OTHERfunctional rehabilitation of social communication
Sponsors
University Hospital, Tours
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
12 Months to 12 Years
Healthy volunteers
No
Inclusion criteria
* re-education of social communication
Exclusion criteria
* multi-handicapped associated to ASD
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Clinical changes between Baseline and Two years | 2 years | Autism Diagnostic Observation Schedule (ADOS) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| neurophysiological evaluations at 1 year | 1 year | Event related potentials (ERPs) Visual ERPs : P100 evoked by pattern reversing checkerboard stimuli , N170 evoked by faces auditive ERPs: N1c and MMN evoked with an oddball pardaigm using simple tones, MMN evoked with an oddball pardaigm using emotional voices |
| neurophysiological évaluations at 2 years | 2 years | Event related potentials (ERPs) Visual ERPs : P100 evoked by pattern reversing checkerboard stimuli , N170 evoked by faces auditive ERPs: N1c and MMN evoked with an oddball pardaigm using simple tones, MMN evoked with an oddball pardaigm using emotional voices |
| Social and cognitive evaluations at baseline | baseline | Social and Cognitive Evaluation Battery (SCEB), |
| Social and cognitive évaluations at 1 year | 1 year | Social and Cognitive Evaluation Battery (SCEB), |
| neurophysiological evaluations at baseline | baseline | Event related potentials (ERPs) Visual ERPs : P100 evoked by pattern reversing checkerboard stimuli , N170 evoked by faces auditive ERPs: N1c and MMN evoked with an oddball pardaigm using simple tones, MMN evoked with an oddball pardaigm using emotional voices |
| Repetitive behaviors évaluations at baseline | baseline | Repetitive and Restrictive Behavior Scale (RRBS) |
| Repetitive behaviors évaluations at one year | 1 year | Repetitive and Restrictive Behavior Scale (RRBS) |
| Repetitive behaviors at two years | 2 years | Repetitive and Restrictive Behavior Scale (RRBS) |
| Social and cognitive évaluations at 2 years | 1 year | Social and Cognitive Evaluation Battery (SCEB), |
Countries
France
Outcome results
None listed