Biomarkers of Ovarian Reserve and Correlation With IVF Treatments

Predictors of Ovarian Response in Women Undergoing Ovarian Stimulation for IVF

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02442895

Enrollment

236

Registered

2015-05-13

Start date

2014-02-28

Completion date

2015-02-28

Last updated

2015-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pregnancy, Ovarian

Keywords

mature oocytes, antral follicles count, follicle stimulating hormone, antimullerian hormone

Brief summary

Retrospective study to evaluate the correlation between AFC, FSHb, AMH and IVF outcomes of 347 cycles performed with three different protocols.

Detailed description

347 IVF cycles (236 patients) analyzed for a retrospective study to evaluate the correlation between the biomarkers of ovarian reserve (antral follicles count, antimullerian hormone, basal follicle stimulating hormone) and number of oocytes and mature oocytes (MII) retrieved during the pick up. For the stimulation were used three different protocols: long luteal, antagonist with daily administration of gonadotropins and antagonist with depot administration of gonadotropins.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Healthy volunteers

Inclusion criteria

* women with primary or secondary infertility underwent ovarian stimulation for in vitro fertilization.

Exclusion criteria

* women who underwent ovarian stimulation for cryopreservation in the presence of neoplastic disease.

Design outcomes

Primary

Measure	Time frame	Description
number of total and mature (MII) oocytes	10 months	the number of total and mature (MII) oocytes retrieved during the pick up.

Secondary

Measure	Time frame	Description
duration of stimulation	10 months	the number of days since the administration of rFSH o corifollitropina alfa until the administration of hCG
ovarian sensitivity index or OSI	10 months	OSI was calculated dividing the total administered FSH dose by the number of retrieved oocytes
pregnancy rate	10 months	the number of positive pregnancy tests with the evidence of an embyo with cardiac activity.

Countries

Italy

Outcome results