Intra-Abdominal Infections
Conditions
Keywords
Abdominal sepsis, Sepsis, Septic shock, Epidemiology, Etiology, Microbiology, Abdomen, Intra-abdominal, Infection, Gastrointestinal tract, Perforation, Peritonitis, Pancreas, Biliary tract, Megacolon
Brief summary
The aim of the project is to perform a multinational, prospective, observational study on IAIs (IntraAbdominal Infections) in critically ill patients; special emphasis will be given to epidemiology and outcomes.
Detailed description
To investigate microbiology and/or drug resistance patterns related to: Geographical region, Source of IAI, Upper GI tract perforation (stomach & duodenum), Lower GI tract perforation (jejunum, ileum, colon, rectum), Primary peritonitis, Peritoneal dialysis-related peritonitis, Intra-abdominal abscess, Pancreatic infection, Biliary tract infection, Typhlitis, Toxic megacolon. To check the Origin of IAI: community-acquired, early-onset healthcare-associated, late-onset healthcare-associated. To describe physician's antimicrobial prescription patterns related to a classification grid that stratifies IAIs according to disease expression, community or healthcare origin, and anatomical disruption. To investigate outcomes (clinical response, need for surgical revision, length of hospitalization, and mortality) related to: Classification of IAI, Severity of acute illness at time of diagnosis (SOFA score) and clinical response after 48-72 hrs. (SOFA score), Processes of care (Time to 1st antimicrobial dose, Time to source control, Type of source control intervention (laparotomy, percutaneous drainage, high volume peritoneal lavage, restoration of anatomy and function), Need for (unplanned) surgical revision (uncontrolled infection source), Frequency of microbiological sampling and delay of results)), Pathogens involved and empirical antimicrobial coverage; special emphasis will be given, to coverage of multidrug resistant Enterobacteriaceae, Pseudomonas aeruginosa, enterococci and Candida species, Duration of antimicrobial therapy, Underlying conditions
Interventions
None listed
Sponsors
European Society of Intensive Care Medicine
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adult (≥18 yrs. of age) * IAI treated with percutaneous or surgical procedure * ICU admission (the patient should either be admitted to the ICU because of abdominal sepsis or should be admitted in the ICU for other reasons and subsequently developed abdominal sepsis as a complication during the ICU course) * Informed consent (if required by local ethics committee)
Exclusion criteria
\<18 yrs
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical response | Clinical response at 3 days |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Surgical revision | within the first week | For the abdominal sepsis cases that were managed with a surgical intervention (most of them), the need for a surgical revision (re-intervention) within the first week after the initial procedure is considered failure of initial source control. The need for an additional surgical intervention within the first week will be assessed. |
| Length of hospitalization | up to 6 months | Length of ICU stay |
| Mortality | During the 6 month study period | Survival status at discharge |
Countries
Belgium
Outcome results
None listed