Hemodynamic Changes After Anesthesia With Propofol: Study of Biomarkers

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02442232

Enrollment

Registered

2015-05-13

Start date

2015-08-31

Completion date

2016-05-31

Last updated

2016-08-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hemodynamic Responses to Propofol

Brief summary

The purpose of this study is to evaluate biomarkers affecting the hemodynamic responses to propofol. Particularly, the investigators will assess the effects of polymorphisms in NOS3 and PRKCA genes on hemodynamic responses to propofol and the effects of these polymorphisms on biomarkers related to nitric oxide after propofol anesthesia. In addition, the investigators will evaluate the effects of propofol anesthesia on biomarkers related to nitric oxide in hypertensive patients chronically treated with angiotensin-converting enzyme inhibitors.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

40 Years to 80 Years

Healthy volunteers

Yes

Inclusion criteria

* ASA I or II * BMI lower 30 kg/m2

Exclusion criteria

* Severe hypertension * Previous stroke * Previous infarction * Uncontrolled respiratory, renal, hepatic and hematological diseases.

Design outcomes

Primary

Measure	Time frame
Systolic blood pressure	10 minutes
Diastolic blood pressure	10 minutes
Mean blood pressure	10 minutes
Heart rate	10 minutes
Plasma nitrite levels	10 minutes
Plasma nitrate levels	10 minutes

Outcome results