Blood Loss, Surgical
Conditions
Keywords
Electrocardiography, Hemorrhage, Monitoring, Intraoperative
Brief summary
QT interval changes is measured during all phases of the operation. The protocol is focusing at intraoperative bleeding events and is also observing QT interval changes during anesthetic and operative procedures.
Detailed description
Prolongation of the QT interval is associated with functional torsade de points, re-entry, and sudden death (see reference). Variations of QT-interval caused by changes in the volume status of the patient during an operation remained unclear. QT interval changes will be monitored during the surgery with the focus of the influence of sudden blood loss, volume substitution by crystalloids, blood and blood products. The effect of surgical procedures on the QT-interval (e.g. clamping of kidney artery) will be observed as well as the association of intra-operative QT-interval alterations with postoperative complications.
Interventions
PROCEDUREintra-operative blood loss
surgery in the urology and orthopedics
Sponsors
Technische Universität Dresden
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* American Society of Anesthesiologists physical status classification 2 - 3 * patients after consent
Exclusion criteria
* Children, * pregnant women, * patients not able to consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| change in QT-time | during operation |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| postoperative incidents/disturbance rhythm of the heart | 2 days | association to intraoperative repolarisation-disturbance / QT-prolongation |
| survival | 1 year | association to intraoperative repolarisation-disturbance / QT-prolongation |
Countries
Germany
Contacts
Primary ContactTorsten Richter, M.D.
Backup ContactJuliane Flaxa, M.D.
Outcome results
None listed