Frontal Lobe Epilepsies
Conditions
Keywords
cooperative behavior, therapy adherence, fMRI
Brief summary
Epilepsy is a frequent neurological disorder with about a third of patients having seizures despite treatment. At least some of these seizures can be linked to a low compliance and therapy adherence of patients. Compliance is defined as the extent to which a person's behavior (in terms of taking medication, following diets, or executing life style changes) coincides with medical or health advice. Therapy adherence of patients suffering from epilepsy is low with reported rates between 30 and 50%, although adherence to anticonvulsive drug therapy is critical for effective disease management and low therapy adherence is associated to higher mortality in epilepsy. The reasons for low therapy adherence are still a matter of research. Some known factors influencing compliance in epilepsy are related to its chronic nature, but others seem to lie in a complex interaction between psychiatric comorbidity and an impairment of neural systems underlying behavior. Furthermore, therapy adherence rests a variable difficult to measure, especially in epileptic patients where classical tools such as questionnaires and electronic monitoring devices have been shown to be imprecise. It has been argued that the term 'compliance' should be replaced by 'co-operative behavior' and non-compliance can therefore be interpreted as troubled co-operative behavior. This behavioral approach offers the potential of using tools and methods of the latest developments in behavioral neuroscience. Neuroeconomics, a scientific field on the border of psychology, economics and neuroscience, has used economic game paradigms in order to operationalize cooperative behavior and to identify several brain areas by functional brain imaging that have been linked to social co-operative behavior. The majority of these brain areas are located in the frontal cortex \[ventromedial frontal/orbitofrontal cortex, and rostral anterior cingulate cortex. Epilepsies originating in the frontal lobe are subsumed under the term frontal lobe epilepsy (FLE) and represent 20-30% of all partial seizures and 25% of all refractory focal epilepsies referred to epilepsy surgery. The investigator's project plans to study compliance and cooperative behavior of patients suffering from frontal lobe epilepsies through a neuroeconomic approach by (1) comparing the behavior of these patients in the prisoners' dilemma game to the behavior of age-, gender-, and education-matched healthy controls, (2) correlation of game behavior to brain activation measured by functional magnetic resonance imaging in both patients and healthy controls and (3) studying the link between cooperative behavior to compliance captured by pill counts and questionnaires.
Interventions
RADIATIONfunctional magnetic resonance imaging exam
Sponsors
Hospices Civils de Lyon
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
(Patients): * Age between 18 and 50 * Diagnosis of frontal lobe epilepsy * Written consent to participate * Right-handed * Hospital Anxiety and Depression Scale Score under 10 * Obsessive Compulsive Inventory Score under 40 * Sufficient language skills * Social insurance Inclusion criteria (controls): * Age between 18 and 50 * Written consent to participate * Right-handed * Hospital Anxiety and Depression Scale Score under 10 * Obsessive Compulsive Inventory Score under 40 * Sufficient language skills * Social insurance
Exclusion criteria
(Patients): * Seizures types other than epileptic (psychogenic etc.) * Mental retardation * Epilepsies other than FLE * Other known neurological diseases * Hospital Anxiety and Depression Scale Score over 10 * Obsessive Compulsive Inventory Score over 40 * Pregnancy * non-MRI suitable transplants (cardiac pacemaker etc.), claustrophobia, orthopedic diseases that prevent lying in the scanner * During exclusion period of other studies * No social insurance
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Social cooperative behavior as measured by the prisoners' dilemma game | 1 day | The prisoners' dilemma game (PDG; Trivers, 1971) is a well-studied game derived from economic game theory that has been used extensively to quantify and study cooperative behavior. The two players in the game can choose between two moves, either co-operate or defect. If both players co-operate, they both receive the reward R. If one player defects, while the other one co-operates, then the defector receives the payoff T while the co-operative player receives the payoff S. If both players defect, they both receive the payoff P. (T \> R \> P \> S). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Scores acquired by questionnaire | 1 day | Several questionnaires to cover beliefs about therapy adherence will be applied. |
| Neuropsychological profile | 1 day | analysis of neuropsychological testing of (working) memory, attention, theory-of-mind and executive functions. |
| Blood-oxygen-level dependent signal during the Prisoners' dilemma game | 1 day | Whole brain analysis of correlation between behavior in the PDG (prisoners' dilemma game) and brain activation as measured by the BOLD (blood-oxygen-level dependent) signal captured through functional MRI as well as group differences between patients and controls. |
| Pill counts | 1 day | Pills taken and not-taken during the study period will be counted as a variable of therapy adherence. |
Countries
France
Outcome results
None listed