Obesity
Conditions
Brief summary
Bariatric surgery may attenuate insulin resistance and low-grade inflammation in obese subjects. This trial aims to test whether exercise training can add to the benefits of bariatric surgery on insulin sensitivity and inflammation. In addition, this study aims to investigate whether exercise training can counteract bone loss induced by bariatric surgery.
Interventions
OTHERExercise training
Exercise training will comprise aerobic and strength exercises
Sponsors
University of Sao Paulo
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* body mass index ≥ 35 kg/m2 * not engaged in physical activity programs * without any physical limitation that could preclude exercise participation
Exclusion criteria
* body mass index \< 35 kg/m2 * regular participation in physical activities programs * cancer or any other disease that could limit participation in exercise
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| insulin sensitivity as assessed by surrogates of insulin sensitivity | 6 months | — |
| body composition as assessed by densitometry (DEXA) | 6 months | bone mass, lean mass and fat mass |
| profile of cytokines | 6 months | — |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| risk of cardiovascular events as assessed by questionnaires (composite) | 6 months | — |
| physical activity level as assessed by accelerometry | 6 months | — |
| depression and anxiety as assessed by questionnaires (composite) | 6 months | — |
| aerobic conditioning as assessed by a cardiopulmonary test. | 6 months | — |
| quality of life as assessed by questionnaires (composite) | 6 months | — |
| muscle function as assessed by a battery of tests | 6 months | timed-stands test, timed-up-ang-go test, maximal strength tests |
Countries
Brazil
Outcome results
None listed