Comparison of Effects of PEEP Levels on Respiratory Mechanics in Patients Undergoing Laparoscopic Cholecystectomy

Comparison of Effects of 3 Different PEEP Levels on Hemodynamic, Respiratory Mechanics and Elimination of Volatile Anesthetic Agent in Patients Undergoing Laparoscopic Cholecystectomy

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02439801

Enrollment

Registered

2015-05-12

Start date

2015-03-31

Completion date

2015-05-31

Last updated

2015-05-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Respiratory System Abnormalities

Keywords

PEEP, compliance, peak airway pressures

Brief summary

Laparoscopic cholecystectomy is accepted as gold standard in the management of cholelithiasis. Although laparoscopic procedures have many advantages,intra-abdominal CO2 insufflation can cause decreased lung volumes and compliance, increased airway resistance and impaired ventilation-perfusion ratio. In this study, investigators aim to investigate effects of intra-operative PEEP treatment at 3 distinct levels on respiratory dynamics and elimination time of volatile anesthetic agent.

Detailed description

In the study, 75 ASA I-II patients aged 30-65 years will be randomized into 3 groups to receive 0 cmH2O PEEP (Group-1), 5 cmH2O PEEP (Group-2) and 8 cmH2O PEEP (Group-3) in PVC mode. In all patients underwent general anesthesia; hemodynamic parameters, Ppeak, Pplateau, compliance values as well as Fisevo/Fexpsevo ratio at 1 MAC and times from 1 MAC to 0.3 and 0.1 MAC will be recorded. In addition, preoperative and postoperative pulmonary function tests will be compared in all patients.

Interventions

PROCEDUREPEEP 0

0 cmH2O positive end expiratory pressure

PROCEDUREPEEP 5

5 cmH2O positive end expiratory pressure

PROCEDUREPEEP 8

8 cmH2O positive end expiratory pressure

Study design

Observational model

CASE_CROSSOVER

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

30 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* ASA (American Society of Anesthesiologists) I-II * BMI of 25-30 * patients scheduled to elective laparoscopic cholecystectomy.

Exclusion criteria

* Patients with ASA III, IV, V risk, * Patients with comorbid diseases that may increase intra-abdominal pressure or pulmonary hypertension, * Patients with renal and hepatic failure, * Patients with pregnancy and * Patients using bronchodilator or steroid were excluded.

Design outcomes

Primary

Measure	Time frame
levels of static-dynamic compliance with intra-operative PEEP treatment at 3 distinct levels	1 month

Secondary

Measure	Time frame
elimination time of volatile anesthetic agent with intra-operative PEEP treatment at 3 distinct levels	1 month
levels of p peak and p plateau pressures with intra-operative PEEP treatment at 3 distinct levels	1 month

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026