Hypovolemia
Conditions
Keywords
stroke volume, haemodynamic, fluid resucitation
Brief summary
In high perioperative risk patients, guidelines suggest intraoperative haemodynamic optimization by measurement of stroke volume (SV) to guide fluid resucitation.This strategy requires an invasive monitoring and learning. Some studies tried to find SV surrogates based on haemodynamic usual parameters. In an experimental hemorrhagic shock, SV was correlated to the pulse pressure (PP) / heart rate (HR) ratio. The investigators hypothesized that SV variations (ΔSV) would be correlated to the PP/HR ratio variations (ΔPP / HR) during fluid challenge, and ΔPP / HR would be able to detect a ΔSV greater than 10%.
Interventions
DRUGfluid challenge of saline
250 ml of saline
Sponsors
University Hospital, Caen
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* a suspected hypovolemia, based on clinical or paraclinical parameters. * a fluid challenge decision at the discretion of the anaesthesiologist physician in charge of the patient.
Exclusion criteria
* Minor or major patient under guardianship, * oesophageal Diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| correlation by linear regression between variations of the ratio PP/HR ( in percentage) and variations of SV ( in percentage) during fluid challenge | 18 months |
Secondary
| Measure | Time frame |
|---|---|
| Area under the receiver operating characteristic curve (AUC roc) of the ability of variations of the ratio PP/HR ( in percentage)during fluid challenge to predict an increase of SV greater than 10% | 18 month |
Countries
France
Contacts
Primary ContactOlivier REBET
Backup ContactJean Luc Hanouz
Outcome results
None listed