Endometriosis
Conditions
Keywords
ovarian endometriomas, AMH, ovarian reserve
Brief summary
Prior studies have shown surgical excision of endometriomas are associated with a decline in ovarian reserve as assessed by serum anti-Mullerian Hormone (AMH) levels. However, the natural history of serum AMH levels in the presence of untreated endometriomas are unknown. Purpose of this study is to determine whether the presence of endometriomas cause a faster decline in serum AMH levels than in healthy women over a six months period.
Detailed description
The study is a prospective cohort study. Women diagnosed with endometriomas by transvaginal or transabdominal ultrasound or MRI will be recruited from a tertiary care endometriosis clinic. Age matched healthy controls will be recruited from the staff of the same hospital. A priorly published historical group of women who underwent endometrioma excision will be a second comparator.
Interventions
PROCEDURElaparoscopic endometrioma excision
OTHERConservative follow up
Sponsors
Uludag University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* Reproductive age * Endometrioma without indication for surgery or treatment with combined contraceptive, progestin or other hormonal intervention.
Exclusion criteria
* Menstrual cycle irregularity * Polycystic ovarian syndrome * Women who were pregnant or contemplating pregnancy in the next six months * History of ovarian surgery * Using medication which could affect ovarian function during six months before recruitment * Indication for surgical excision
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in Serum Anti- mullerian hormone (AMH) level | at recruitment and six months later |
Countries
Turkey (Türkiye)
Outcome results
None listed