Psychological Stress
Conditions
Brief summary
The investigators propose to evaluate the potential utility of stress-related biomarkers obtained via dried blood spots (DBS) and retinal scans by collecting new data from mothers and children within the New Haven MOMS Partnership, a well-established community-partnered research setting. The proposed research could greatly advance the application of stress-related biomarkers within community-based research by increasing our understanding of how stress, trauma, and depression influence biology in childhood and adulthood, as measured using minimally-invasive approaches.
Interventions
OTHERBiological Sample Collection
Anthropomorphic biomarkers including height, weight, heart rate, and blood pressure will be taken for each participating mother and child by a research assistant trained to accurately perform these procedures. Blood spots will be collected in finger stick proficiency, using trigger activated lancets to administer finger sticks. Each participating mothers and child will provide a saliva sample using Oragene DNA saliva collection kits
Sponsors
Yale University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
21 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* English-speaking adult mothers (age 21 or older) of at least one biological child mothers must be able to answer three verification questions to confirm they are the biological parent of their child
Exclusion criteria
* Non-english speakers * Women not able to provide informed consent and with no biological children * Mothers under the age of 21
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of Mother-Child Dyads Who Complete Assessments & Biological Samples | End of study (approximately 5 years) | Feasibility outcome |
| Telomere Length | At baseline-After 90 minutes | Telomere length will be measured using an adapted method of the Cawthon Telomere Assay |
| Advanced Glycation End Products (AGEs) | At baseline-After 90 minutes | AGEs or (advanced glycation endproducts) will be measured using a painless non- invasive retinal scanning device that measures autofluorescence of the crystalline lens of the eye |
Countries
United States
Outcome results
None listed