Idiopathic Lung Fibrosis, Idiopathic Pulmonary Fibrosis
Conditions
Keywords
Mass spectrometry, Exhaled breath analysis
Brief summary
The aim of the study is to answer the question whether a disease specific profile of breath in patients with idiopathic lung fibrosis can be detected by an untargeted metabolomic study using exhaled breath analysis by mass spectrometry.
Interventions
OTHERNo intervention
Sponsors
Swiss Federal Institute of Technology
Swiss National Science Foundation
University of Zurich
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
40 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
1. Clinical symptoms consistent with IPF 2. Age 40 through 80 years 3. Diagnosis of UIP or IPF by HRCT and surgical lung biopsy as outlined in table 1. Only patients fulfilling the category YES will be included in the study. 4. Extent of fibrotic changes (honeycombing, reticular changes) greater than extent of emphysema on HRCT scan 5. No features supporting an alternative diagnosis
Exclusion criteria
1. Acute exacerbation within the last 6 weeks. 2. Any relevant lung disease other than pulmonary fibrosis. 3. Acute inflammatory disease (e.g. common cold) within the last 6 weeks. 4. Acute or chronic hepatic disease. 5. Renal failure or renal replacement therapy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| IPF-specific mass spectrometric profile of volatile organic compounds of exhaled breath analysis (markers of IPF in exhaled breath) | 1 day |
Countries
Switzerland
Outcome results
None listed