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Nitrate for High Intensity Intermittent Exercise

The Effect of Nitrate Supplementation on Sport Performance: High Intensity Intermittent Performance in Recreational Athletes

Status
Completed
Phases
Phase 4
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT02436629
Acronym
NITR-ITE
Enrollment
40
Registered
2015-05-07
Start date
2015-05-31
Completion date
2016-07-31
Last updated
2016-07-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

High Intensity Intermittent Sports Performance

Keywords

Red beetroot juice, High intensity intermittent exercise, Nitrite, Soccer

Brief summary

The objective of the current study is to assess the effect of 6-day dietary nitrate ingestion on high intensity intermittent sports performance in recreational soccer players.

Detailed description

Oral ingestion of nitrate (NO3-) in the form of both nitrate salts and concentrated red beetroot juice has been shown to significantly lower blood pressure at rest and to improve exercise performance during cycle time trials. Furthermore, a positive exercise performance effect of nitrate ingestion has been observed in recreational athletes during intermittent exercise. However, this was achieved after acute supplementation with a substantial dose of dietary nitrate. Whether similar ergogenic effects of nitrate supplementation can be achieved with a more conventional 6-day nitrate supplementation protocol with a lower daily dose remains to be established. Based on the gaps in current literature, our main goal will be to gain further insight into the effects of a 6-day nitrate supplementation protocol on high intensity intermittent exercise performance in recreational athletes.

Interventions

DIETARY_SUPPLEMENTNitrate-rich concentrated beetroot juice

James White, Beet It Sport Shot, 70ml (Standard)

DIETARY_SUPPLEMENTNitrate-depleted concentrated red beetroot juice

Beet It Sport Shot, 70ml (Placebo)

Sponsors

Maastricht University Medical Center
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender
MALE
Age
18 Years to 40 Years
Healthy volunteers
Yes

Inclusion criteria

* Healthy P * Players of the first two senior selection teams of a regional soccer club competing at the 3rd KNVB level or higher * Training ≥2 days a week * 18-40 years * Male

Exclusion criteria

* Use of medication * Injury prohibiting them from performing the exercise protocol effectively * Smoking * Currently supplementing diet with nitrate * Lactose intolerance

Design outcomes

Primary

MeasureTime frame
Total distance covered during the Yo-Yo Intermittent Recovery 1 test (Yo-Yo IR1 test)Performance 3 hours post red beetroot juice ingestion

Secondary

MeasureTime frame
Plasma concentration of nitrite and nitrateConcetrations 3 hours post red beetroot juice ingestion
Salivary concentration of nitrite and nitrateConcetrations 3 hours post red beetroot juice ingestion

Other

MeasureTime frameDescription
Baseline characteristics30 min during visit 1 (Screening)Height, body weight, age, BMI

Countries

Netherlands

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026