Osteoarthritis
Conditions
Keywords
Pulsed radiofrequency, osteoarthritis
Brief summary
Pulsed radiofrequency (PRF) is designed to alleviate pain by delivering an electrical field and heat bursts at a temperature less than 42°C to neural tissue. In contrast with conventional radiofrequency, PRF is controlled below 42°C without damage to nerves and many studies have shown its benefits in pain relief for certain kinds of chronic pain conditions. For lessening pain of certain joint arthropathy, the direct nerve block by application of PRF is difficult and complicated because the supplying nerve of joint is complex or small. Hence, some authors perform intra-articular PRF on the chronic painful joint for example, knee osteoarthritis, atlantoaxial joint, cervical facet joint sacroiliac joint, scapholunate and shoulder joint and the excellent long-term effects are reported. The purpose of this study is to investigate the effect of intra-articular PRF in osteoarthritis.
Detailed description
Pulsed radiofrequency (PRF) is designed to alleviate pain by delivering an electrical field and heat bursts at a temperature less than 42°C to neural tissue. In contrast with conventional radiofrequency, PRF is controlled below 42°C without damage to nerves and many studies have shown its benefits in pain relief for certain kinds of chronic pain conditions. For lessening pain of certain joint arthropathy, the direct nerve block by application of PRF is difficult and complicated because the supplying nerve of joint is complex or small. Hence, some authors perform intra-articular PRF on the chronic painful joint for example, knee osteoarthritis, atlantoaxial joint, cervical facet joint sacroiliac joint, scapholunate and shoulder joint and the excellent long-term effects are reported. However, the definite effect of intra-articular PRF for osteoarthritis from current published studies are insufficiently proved because of small patient numbers and lack of placebo-controlled design. The purpose of this study is to investigate the effect of intra-articular PRF in osteoarthritis.
Interventions
DEVICEpulsed radiofrequency (Neurotherm NT1000, Neurotherm Inc., USA)
Intra-articular pulsed radiofrequency (Neurotherm NT1000, Neurotherm Inc., USA) in treated joint
Sponsors
Tri-Service General Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
30 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Age between 30-75 year-old * Clear consciousness * No receive steroid injection, hyaluronic acid, platelet rich plasma in past 6 months * The pain (VAS) more than 4 * Symptom duration at least 6 months
Exclusion criteria
* Cancer * Joint contracture * Coagulopathy * Pregnancy * Status of Pacemaker * Inflammation status * Operative history of treated joint
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change from baseline of pain on1st, 2th, 4th, 8th,12th and 16th weeks after treatment. | Pre-treatment, 1st, 2th, 4th, 8th,12th and 16th weeks after treatment. | Using the Visual analog scale (VAS) to measure the pain scale before treatment and multiple time frame after treatment. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change from baseline in severity of symptoms and functional status on1st, 2th, 4th, 8th,12th and 16th weeks after treatment. | Pre-treatment, 1st, 2th, 4th, 8th,12th and 16th weeks after treatment. | Use the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) to measure the symptoms and functional status before treatment and multiple time frame after treatment. |
| Change from baseline of range of motion on1st, 2th, 4th, 8th,12th and 16th weeks after treatment. | Pre-treatment, 1st, 2th, 4th, 8th,12th and 16th weeks after treatment. | Use the goniometer to measure the ROM before treatment and multiple time frame after treatment. |
| Change from baseline of strength on 4th, 8th,12th and 16th weeks after treatment. | Pre-treatment 4th, 8th,12th and 16th weeks after treatment. | Use the isokinetic machine to measure the ROM before treatment and multiple time frame after treatment. |
Countries
Taiwan
Outcome results
None listed