Dietary Phosphate and Serum Phosphorus

Nutrition Risk Screening in Chronic Kidney Disease (CKD) From the National Health and Nutrition Examination Survey

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02435017

Enrollment

7895

Registered

2015-05-06

Start date

2003-01-31

Completion date

2009-07-31

Last updated

2018-09-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Phosphorus Metabolism Disorders

Keywords

kidney disease, recommended dietary allowances, nutrition assessment, food, dietary proteins, Vitamin D, dietary fats, ethnology, Continental Population Groups, Phosphorus, dietary, Phosphorus/analysis

Brief summary

Overall study design is to review National Health and Nutrition Examination Survey (NHANES) data 1999-2008 for nutrition risk according to kidney function. Substudies will be performed to review the association of nutrients and overall dietary intake compared to biomarkers available in NHANES during this period.

Detailed description

Data from NHANES 2003-2006 were used to evaluate the relationship between estimated dietary phosphorus intake and the measured serum phosphorus. The following variables were used: 1. Demographics: Age, sex, race/ethnicity 2. Dietary variables: Foods, food groups (as reported by the United States Department of Agriculture (USDA) method, further standardized to the Academy of Nutrition and Dietetics method for portion size and then divided into groups having inorganic phosphate additives or no inorganic phosphate additives), food weight (g), phosphorus (mg), dietary supplements 3. Socioeconomic variables: education, family income 4. Laboratory variables: serum creatinine, phosphorus; urine albumin, creatinine 5. Clinical assessments: hypertension (proportion having blood pressure ≥140 millimeters of mercury (mmHg) diastolic or ≥90 mmHg systolic or taking antihypertensive medications); hyperglycemia (proportion having serum glucose \>126 mg/dL or taking medications for diabetes); kidney function based on Chronic Kidney Disease Epidemiology Collaboration (2009) equation, evaluated in 15 milliliters/min/1.73m2 increments from \<15 to \>105; anthropometrics (BMI, kg/m2; obesity class I, II, III)

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

20 Years to 85 Years

Healthy volunteers

Yes

Inclusion criteria

* Serum creatinine

Exclusion criteria

* Pregnancy * No dietary intake interview * Dietary intake interview not valid * Answered the question Have you had dialysis in the past year? as Yes

Design outcomes

Primary

Measure	Time frame	Description
Serum phosphorus concentration	approximately 24 hours	Serum phosphorus concentration on the day that 24-hour dietary recall was obtained (reflecting dietary intake the day prior to blood draw); measured in mg/dL

Secondary

Measure	Time frame	Description
Kidney function level	Baseline	Kidney function estimated from Chronic Kidney Disease Epidemiology Collaboration (2009) equation, mL/min/1.73m2, and separated into 15mL/min increments

Outcome results