The Relationship Between Peripheral Arterial Disease and Mitochondrial Respiratory Capacity

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02434783

Enrollment

Registered

2015-05-05

Start date

2015-05-31

Completion date

2016-04-30

Last updated

2016-08-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Intermittent Claudication

Keywords

Blood circulation, Blood vessels, Mitochondria, Muscle, skeletal, Legs, Energy metabolism

Brief summary

Current evidence cannot explain the clinical features of peripheral arterial disease only from the principle of reduced blood flow. Explanations have therefore in addition been linked to mitochondrial dysfunction of skeletal muscles. This study will elucidate whether there is a relation between clinical variables of the different levels of arterial insufficiency in peripheral arterial disease and mitochondrial respiratory capacity.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Healthy volunteers

Yes

Inclusion criteria

* Asymptotic peripheral arterial disease (Ankle-brachial index \< 0.9), intermittent claudication (Ankle-brachial index 0.4 - 0.9), or critical limb ischemia (Ankle-brachial index \< 0.4)

Exclusion criteria

* Diagnosed with intermittent claudication secondary to vascular insufficiency * Warfarin or heparin usage * Underwent a vascular intervention in the last 6 months * Active cancer, renal- or liver disease

Design outcomes

Primary

Measure	Time frame	Description
mitochondrial respiratory capacity	1 hour	measured in oxygen glux in pmol.s-1.mg-1, using mitochondrial respirometry on an Oxygraph-2k (Oroboros Instruments, Austria).

Countries

Norway

Outcome results