Bacteriology
Conditions
Keywords
antibiotics resistance integrons, neonatology newborns, digestive acquisition, dynamic of the acquisition of integrons
Brief summary
Antibiotic resistance is a major public health issue as multiresistant bacteria (MRB) are increasing. Among the actions to control resistance, one is an interesting lead: to prevent the emergence of resistant bacteria by limiting possibilities for bacteria to acquire resistance. Mechanisms of resistance genes acquisition are deeply studied but there are few data on the dynamic of acquisition over time. Among the genetic components that disseminate resistance genes, resistance integrons (RI) play a major role in the acquisition and dissemination of antibiotic resistance in gram-negative bacteria. The digestive tract of the newborn (NB), which is initially sterile, is colonized by a bacterial microbiota during the first days of life. It thus appears to be an appropriate model to study the dynamic of resistance acquisition. This project intends to follow the NB of neonatology over time in order to study the dynamic of the digestive acquisition of RI and MRB
Interventions
None listed
Sponsors
University Hospital, Limoges
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
No minimum to 1 Days
Healthy volunteers
No
Inclusion criteria
* Mother-child pairs that will be included in the study will be the pairs of all the NB, born in the center (in born) and hospitalized in the neonatology units of each center: with a predictable stay ≥ 3 weeks in the unit
Exclusion criteria
NB will not be included if: * They exhibit a birth defect, especially on the digestive tract * They are secondarily hospitalized after a postnatal transfer (out born). * The parents express their objection for the child to take part in the study * The stool sample of the mother has not been received
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The occurrence over time of digestive acquisition of any type of RI | 3 weeks |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The occurrence over time of digestive acquisition of severals type of RI | 3 weeks | intI1 whenever the gene encoding a class 1 integrase will be detected intI2 whenever the gene encoding a class 2 integrase will be detected intI3 whenever the gene encoding a class 3 integrase will be detected An association: intI1+intI2, intI1+intI3, intI2+intI3, intI1+intI2+intI3 will also be searched. |
| Occurrence over time of digestive acquisition of MRB in NB hospitalized in neonatology units | 3 weeks | Occurrence over time of digestive acquisition of MRB in NB hospitalized in neonatology units |
Countries
France
Outcome results
None listed