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The Bilateral Deficit Phenomenon, Functional and Dynamometric Assessment in Postmenopausal Women

The Bilateral Deficit Phenomenon, Functional and Dynamometric Assessment in Postmenopausal Women

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT02434185
Enrollment
20
Registered
2015-05-05
Start date
2015-03-31
Completion date
2015-04-30
Last updated
2018-10-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Muscle Weakness, Postmenopausal Syndrome

Keywords

Musculoskeletal Physiological Phenomena, Postmenopause, Muscle Strength, Absorptiometry, Photon

Brief summary

The bilateral deficit phenomenon (BLD) is defined as an inability of the neuromuscular system to generate maximal force when two homonymous limb operate simultaneously (bilateral contraction) with respect to the force developed when both limbs acts separately (unilateral contraction). From an applied perspective, movement patterns of bilateral homonymous limb are often developed during activities of day living, e.g. rising from a chair or opening a jar. The BLD can be considered an intrinsic property of the human neuromuscular system but could be enough important to constitute a performance-limiting factor for postmenopausal women that involves a degenerative loss of muscular strength. Therefore, a specific analysis of this phenomenon and its relation with activities of daily living, such as climbing a step and rising from a chair, is crucial for detecting variables of neuromuscular performance and develop strategies to minimize the loss of strength.

Detailed description

* 20 postmenopausal women unexperience in strength training or resistance training, without musculoskeletal, neurological diseases, and cardiovascular limiting-diseases were recruited. * Maximum strength of lower limbs during leg-press exercise was measured for future analysis. * The force-time curves were measured during climbing a step and rising from a chair. * A fragility phenotype test was applied to the subjects to determine frailty phenotype classification, including; weight loss of greater than 10 lbs in the past 12 months, maximal handgrip strength, time to walk 15-ft at usual pace, self-reported leisure time physical activity, and self-reported exhaustion. * The anthropometric measurements were performed by dual energy X-ray absorptiometry.

Interventions

None listed

Sponsors

Universidad Católica San Antonio de Murcia
Lead SponsorOTHER

Study design

Observational model
OTHER
Time perspective
CROSS_SECTIONAL

Eligibility

Sex/Gender
FEMALE
Age
50 Years to 70 Years
Healthy volunteers
Yes

Inclusion criteria

* Postmenopausal women

Exclusion criteria

* Unexperienced in strength training or resistance training. * Not musculoskeletal diseases. * Not neurological diseases. * Not cardiovascular limiting-diseases. * Not fragility or pre-fragility phenotype.

Design outcomes

Primary

MeasureTime frame
Assess the force-time curve during climbing rising from a chairScreening visit
Assess bone mineral-free lean tissue mass by dual energy X-ray absorptiometryScreening visit
Assess the fragility phenotype of the subjectsScreening visit
Assess the rate of force developed in time intervals (0-50, 50-100, 100-150ms) of lower limbs during bilateral and unilateral contractionScreening visit
Assess fat-tissue mass and lean-tissue mass compositionScreening visit
Assess the maximum force of lower limbs during bilateral and unilateral contractionScreening visit
Assess the force-time curve during climbing a stepScreening visit

Countries

Spain

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 8, 2026