Asthma
Conditions
Brief summary
"CHildhood ASthma and Environment Research study - CHASER study" is an observational longitudinal study in outpatient clinic of Pediatric Allergology & Pulmonology (PAP) of Respiratory Disease Research Center (RDRC) within the Institute of Biomedicine and Molecular Immunology (IBIM) of the National Research Council (CNR) of Palermo (RDRC-IBIM CNR), Italy. The first phase - transversal study will identify determinants of pediatric asthma control The second phase - longitudinal study, in patients with persistent asthma, will be focused on: * predictors for asthma exacerbations and loss of control * real life adherence to asthma therapy guidelines * phenotypic characterization through the collection of saliva samples * assessment of alterations and inflammatory changes in the nasal mucosa through nasal brushing * evaluation of the presence of 8-isoprostane, nicotine, cotinine and bisphenol-A through urine analysis. Chaser Project is expected to improve the knowledge of pediatric asthma in patients with different level of control, identifying predictors for asthma exacerbations and loss of control.
Interventions
None listed
Sponsors
Stefania La Grutta, MD
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
5 Years to 16 Years
Healthy volunteers
No
Inclusion criteria
* age 5-16 years * asthma * not asthma
Exclusion criteria
* chest deformity * active smoking
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Asthma | 5 years |
Secondary
| Measure | Time frame |
|---|---|
| Measures from saliva samples | 5 years |
| Measures from nasal brushing | 5 years |
| Measures from urine samples | 5 years |
Countries
Italy
Outcome results
None listed