Oral Carbohydrate in DM Patients Undergoing Total Knee Arthroplasty

Effect of Preoperative Oral Carbohydrates on Postoperative Nausea and Vomiting and Quality of Recovery in DM Patients Undergoing Total Knee Arthroplasty

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02432781

Enrollment

Registered

2015-05-04

Start date

2015-06-25

Completion date

2017-12-14

Last updated

2018-09-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Total Knee Arthroplasty

Brief summary

The primary purpose of this study is to investigate the effects of carbohydrate-rich drink on postoperative nausea and vomiting in diabetic patients undergoing total knee arthroplasty. The secondary purpose is to investigate the effects of carbohydrate-rich drink on quality of recovery and inflammation in diabetic patients after total knee arthroplasty.

Detailed description

Carbohydrate-rich drink has been proved to neither delay gastric emptying nor affect gastric acidity and is therefore considered safe to use in elective surgical patients without risk factors for pulmonary aspiration. It reduced postoperative nausea and vomiting and improved sense of well-being after surgery. Moreover, carbohydrate-rich drink was not found to be affected by delayed gastric emptying in patients with uncomplicated type 2 diabetes. Therefore, carbohydrate drink may be safely administered 3 h before anesthesia without risk of hyperglycemia or aspiration.

Interventions

DIETARY_SUPPLEMENTCarbohydrate-rich drink

DIETARY_SUPPLEMENT10% dextrose solution mixed with insulin 16 unit 100 mL/h

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

19 Years to No maximum

Healthy volunteers

Inclusion criteria

* Type 2 DM patients undergoing elective total knee arthroplasty

Exclusion criteria

* Contraindication to regional anesthesia * Patients whose operation is scheduled to start after 9:00 am * Dementia or cognitive dysfunction * HbA1c \> 8% * Gastroesophageal reflux disease

Design outcomes

Primary

Measure	Time frame
Incidence of postoperative nausea and vomiting	24 hours

Secondary

Measure	Time frame	Description
Score of quality of recovery	24 hours	Quality of recovery is determined by a 40-item quality-of-recovery questionnaire
Degree of inflammation	24 hours	Degree of inflammation is determined by white blood cell count, neutrophil count, and C-reactive protein

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026