Hyperparathyroidism
Conditions
Keywords
F18-choline
Brief summary
The rationale for the proposed pilot study is to investigate the ability of PET-CT with F18-choline to detect and locate the parathyroid adenoma in patients with primary hyperparathyroidism and negative or non-contributory MIBI (Tc-99m sestamibi) and cervical ultrasound, in order to avoid unnecessary bilateral cervical exploration.
Interventions
RADIATIONF18-choline PET examination
F18-choline PET examination will be performed before surgery
Sponsors
Centre Francois Baclesse
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patient aged 18 years or more; * Patient with a primary hyperparathyroidism and witj a negative or non-contriburatory MIBI parathyroid scintigraphy and neck ultrasonography, for which surgical resection is planned; * Confirmation of the diagnosis of primary hyperparathyroidism on laboratory tests * Affiliate to a social security system; * Patient written informed consent.
Exclusion criteria
* Patient deprived of liberty, under guardianship; * Any medical or psychological condition witch could compromise the capacity of the patient to participate in the study; * Pregnant or breastfeeding
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Sensitivity (ability to identify and visualize the parathyroid adenoma) | Up to 2 months | Sensitivity of PET-CT with F18-choline (FCH) to identify and visualize the parathyroid adenoma in patients with primary hyperparathyroidism and negative or non-contributory parathyroid scintigraphy MIBI and cervical ultrasound |
Countries
France
Outcome results
None listed