AIDS-Related Dementia Complex
Conditions
Keywords
Optical Coherence Tomography
Brief summary
The purpose of this study is to determine the sensitivity and specificity of the use of optical coherence tomography to detect HIV-associated neurocognitive disorder compared to MRI and usual cognitive screening tools.
Interventions
OTHEROptical Coherence Tomography
Optical Coherence Tomography provides a non invasive evaluation of the thickness of different layers of the retina
Sponsors
Fonds iris-Recherche, Fondation Roi Baudouin, Belgium
Centre Hospitalier Universitaire Saint Pierre
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* HIV infection * Antiretroviral treatment * Undetectable plasmatic HIV viral load (viral load\<50 copies/ml) for at least 6 months * Ability to understand and give approved consent
Exclusion criteria
* Any present or past ophthalmologic illness that may impair OCT results * Previous cerebral infection with sequel * Previous cerebrovascular disease with sequel * Severe psychiatric illness * Active alcohol or drug abuse * Active chronic hepatitis C * Inability to perform french cognitive assessment * Inability to perform a MRI * Inability to perform a lumbar puncture
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of patients with abnormal OCT (retinal thickness in µm) in patients with abnormal full neurocognitive evaluation | Baseline |
Secondary
| Measure | Time frame |
|---|---|
| Number of patients with abnormal neuroscreen and/or modified dementia scale in patients with abnoraml full neurocognitve evaluation | Baseline |
| Correlation between retinal thickness (in µm) and cerebral atrophy in % of brain parenchymal fraction ( measured by cerebral MRI) | Baseline |
Countries
Belgium
Outcome results
None listed