Fever
Conditions
Keywords
Child, outpatient, premedication
Brief summary
Anticholinergic drugs have traditionally been used for their antisialagogue properties. But use of anticholinergic drugs can interfere with thermoregulation via inhibition of the parasympathetically mediated sweat secretion. Sweating inhibition can reduce heat elimination, and children's thermoregulation depend more on sweating than adults and they can become hyperthermic when given these agents. The investigators evaluated the fever-causing effects of adjunctive anticholinergics in children under general anesthesia using ketamine.
Interventions
DRUGGlycopyrrolate
Intravenously administered 0.005mg/Kg of glycopyrrolate in intervention group
Sponsors
Inje University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
12 Months to 8 Years
Healthy volunteers
No
Inclusion criteria
* American Society of Anesthesiologists (ASA) Physical Status classification I * underwent surgery between 8 to 9 am * undergoing ambulatory anesthesia with ketamine
Exclusion criteria
* who required endotracheal intubation * who were administered with medications other than ketamine
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Body temperature | every 30 minutes from base line ( up to 90min ) | measured body temperature at three times in both ears and the highest value was selected. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Oral secretion (VAS) | up to operative end | Oral secretion during the whole procedure was recorded by the researcher |
Countries
South Korea
Outcome results
None listed