Healthy
Conditions
Keywords
Pulmonary aerosol distribution, SPECT-CT analysis, High flow nasal cannula, Vibrating-mesh nebulizer, Jet nebulizer
Brief summary
Vibrating-mesh nebulizers ensure currently the best deposition output and are recommended in routine use in intensive care unit. However, jet nebulizers remain the most frequently used nebulizers. On a bench study, aerosol delivery through a high flow nasal cannula (HFNC) was increased using a vibrating-mesh nebulizer as compared to a jet nebulizer. Lung distribution of nebulized particles delivered through a HFNC has never been investigated in vivo. The aim of this study was to compare aerosol lung distribution with both nebulizers through a HFNC by SPECT-CT.
Interventions
OTHERSingle photon emission computed tomography
Imaging technique to investigate lung aerosol distribution
OTHERSpirometry
FEV1, FVC assessment
DEVICEAeroneb Solo
99mTc-DTPA solution placed on the nebulizer reservoir
DEVICEJet Nebulizer
Sponsors
Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Masking
DOUBLE (Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
MALE
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy respiratory function
Exclusion criteria
* Pulmonary disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pulmonary deposition | Immediately after nebulization by imaging technique, expected average of 15 minutes | Single photon emission tomography combined with a CT-scan |
Secondary
| Measure | Time frame |
|---|---|
| Three-dimensional penetration index | immediately after the nebulization by imaging assessment, expected average of 30 minutes |
Other
| Measure | Time frame |
|---|---|
| Spirometry | Baseline |
Countries
Belgium
Outcome results
None listed