Blood Loss
Conditions
Keywords
tourniquet, total knee arthroplasty, blood loss
Brief summary
Tourniquets are still widely used in total knee arthroplasty, but are associated with several adverse effects. Most of previous studies did not randomize the participants so the baseline difference of the patients might have influenced the outcome. Therefore, investigators conducted a randomized controlled trial, in which all the patients received staged bilateral TKA with two different durations of tourniquet use. Investigators aimed to quantify the effect of tourniquet use on reducing blood loss and to evaluate the impact of tourniquet use on functional and clinical outcome.
Detailed description
Fifty participants who underwent staged bilateral TKA were recruited in this study. On one side, the tourniquet was inflated immediately before incision and deflated after the hardening of the cement. On the other side the tourniquet was inflated immediately before cement application and deflated after its hardening. Blood loss, operating time, transfusion rate, postoperative pain, limb swelling, deep vein thrombosis (DVT) incidence and clinical outcomes were monitored for comparison.
Interventions
PROCEDUREShort-duration tourniquet
Short-duration tourniquet group:inflate the tourniquet immediately before cement application and deflated after its hardening
PROCEDURELong-duration tourniquet
Long-duration tourniquet group: inflate the tourniquet immediately before incision and deflated after the hardening of the cement
Sponsors
Peking University People's Hospital
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
50 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* patients aged 50 years or over * classified as American Society of Anesthesiologists ASA 1-2.
Exclusion criteria
* coagulopathy, * uncontrolled hypertension, * peripheral vascular disease and * patients with BMI≥35
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intraoperative blood loss | within operation |
Secondary
| Measure | Time frame |
|---|---|
| Thigh pain measured by Visual Analogue Scale/Score (VAS) | 1 day, 2 day, 1 week, 2 week and 6 week after surgery |
| Thigh swelling measured by circumference 10 cm proximal to the patella | 1 day, 2 day, 1week, 2 week and 6 week after surgery |
| Postoperative blood loss measured by drainage volume | 1 day and 2 day after surgery |
Outcome results
None listed