Polycystic Ovary Syndrome (PCOS)
Conditions
Keywords
Polycystic Ovary Syndrome (PCOS)
Brief summary
The aim of this project is to investigate the pathophysiology of PCOS in regards to the metabolic profile including defects in insulin sensitivity in skeletal muscle and adipose tissue, and to investigate the effects of exercise training on these parameters.
Interventions
OTHER14 weeks exercise training
Sponsors
University of Copenhagen
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
Women with PCOS * Hyperandrogenism and/or hyperandrogenemia * Regular menstruation * Age: 20-40 * Inactive or low physical activity level * Low to moderate fitness status Inclusion Criteria: Women without PCOS * Normal levels of plasma androgens * Polycystic ovary and/or menstrual dysfunction * Age: 20-40 * Inactive or low physical activity level * Low to moderate fitness status
Exclusion criteria
Women with and without PCOS * Pregnancy or breast feeding * Smoking * Use of birth control pills 3 mo before enrolment
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Compliance to exercise training program as assessed by number of training sessions completed | 14 weeks | Superviced training program - no. of training sessions are noted by trainer. Compliance must be higher than 80%. |
| No change in Body Weight | 14 weeks | — |
| Component of metabolic syndrome | 14 weeks | Hole body insulin sensitivity measured by HOMA index |
Countries
Denmark
Outcome results
None listed