Active Emergence From General Anesthesia
Conditions
Brief summary
The aim of this study is to test the hypothesis that methylphenidate actively induces emergence from propofol and sevoflurane general anesthesia in healthy volunteers.
Detailed description
Basic science and clinical data suggest that activation of one or more of the brain's arousal pathways is a highly plausible way to induce active emergence from general anesthesia. The investigators have compelling experimental data demonstrating that methylphenidate is highly effective in actively inducing emergence from isoflurane and propofol general anesthesia in rodents. The available literature suggests that IV methylphenidate would be safe to administer to patients recovering from general anesthesia, and that in addition to promoting arousal, it would enhance breathing. Both of these effects would be highly desirable in patients recovering from general anesthesia.
Interventions
IV methylphenidate will be administered to induce emergence from general anesthesia.
DRUGPlacebo
normal saline
DRUGSevoflurane
Inhaled anesthetic
DRUGPropofol
IV anesthetic
Sponsors
Massachusetts General Hospital
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 36 Years
Healthy volunteers
Yes
Inclusion criteria
1. Age 18-36 years 2. ASA classification 1 or 2 3. Normal body weight, BMI ≤ 30 4. Non-smoker 5. Right handed 6. No history of taking stimulants
Exclusion criteria
* In general, patients will be excluded from the study if the state of their chronic health problems gives them an ASA physical status classification of 3 or beyond.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Response to methlyphenidate administration | minutes to response, expected average is less than 10 minutes | The number of minutes from the administration of methylphenidate until subjects respond to verbal commands |
Outcome results
None listed