Multiple System Atrophy, Parkinson's Disease
Conditions
Keywords
differential diagnosis, multimodal MRI, Parkinson's Disease, Multiple System Atrophy
Brief summary
Based on previous promising results, the next step for the validation of a multimodal MRI method in diagnosis and follow up of patients reached by parkinsonian syndromes is (i) to test whether the multimodal neuroimaging is able to discriminate at the individual level, patients with multiple system atrophy parkinsonism (MSA) and patients with idiopathic Parkinson's disease (PD) (ii) to determine whether the method is sensitive to measure changes over time for the two diseases, according to imaging, neuropsychological and other clinical data. Patients will be compared with healthy controls.
Detailed description
30 patients with PD, 30 patients with MSA and 30 healthy controls will be examined in a 3Tesla MRI. The aim of our project is to demonstrate that our multimodal MRI method can discriminate both diseases with a similar clinical presentation and monitor the progress of the disease. CIC's expertise in recruitment and assessment of patients, and the powers of the INSERM U825 in terms of development and processing in neuroimaging guarantee the feasibility of the project and its successful completion.
Interventions
OTHERMRI acquisition
MRI acquisitions
BEHAVIORALbehavioral evaluations
Evaluations about motor abilities, sleep, cognition and lifestyle
Sponsors
Institut National de la Santé Et de la Recherche Médicale, France
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* informed consent signed * right handed patients * Mini Mental Score \> 22 * no other neurological disease than Parkinson's Disease (PD) or Multiple System Atrophy (MSA) * non-demented patients reached by PD or MSA (according to diagnosis criteria from UK PD Brain Bank and from Gilman and colleagues, 1998, for PD and MSA respectively) * for PD patients only : Hoehn and Yahr score from 2 to 3
Exclusion criteria
* claustrophobia * contraindications to MRI (cardiac or auditive prothesis, pacemakers, cerebral clip, stimulating electrodes) * pregnant women * major neuropsychiatric disease * refusal to be informed in case of cerebral anomaly detected during MRI acquisition * uncompensated thyroid deficit
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome measure to discriminate individual patients and patients with MPI and AMS through multimodal MRI isolating multiparametric spatial signature resulting from a combination of markers in multimodal imaging. | 1 year |
Secondary
| Measure | Time frame |
|---|---|
| correlate MP and MSA disease severity with extracted multimodal MRI biomarkers in whole brain | 1 year |
Countries
France
Outcome results
None listed