Corneal Changes After Crosslinking in Keratoconus Patients Compared to the Untreated Fellow Eye

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02428166

Enrollment

Registered

2015-04-28

Start date

2015-02-28

Completion date

2017-03-31

Last updated

2017-12-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Keratoconus

Keywords

crosslinking, keratoconus, keratometry, pachymetry, pentacam

Brief summary

The purpose of this retrospective study is to assess corneal changes (keratometry, pachymetry) and change in visual acuity (VA) in keratoconus patients after unilateral crosslinking treatment compared to the untreated fellow eye. The corneal measurements obtained preoperatively and 2 to 14 months postoperatively using a Pentacam rotating scheimpflug camera are analyzed. Furthermore, pre-existing or actual ocular pathology or/and ocular surgeries as potential factors involved in treatment outcome are also evaluated.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 50 Years

Healthy volunteers

Inclusion criteria

* Keratoconus patients after unilateral crosslinking treatment

Exclusion criteria

* Morphological changes of the cornea caused be ocular infection or trauma (e.g. corneal scarring) * Other pre-existing corneal surgery (e.g. corneal transplantation, implantation of intrastromal corneal ring segments)

Design outcomes

Primary

Measure	Time frame
Change in maximum keratometry (Kmax) as measured by the Pentacam HR	after completion of data collection based on the measurements preoperatively and 2-14 months postoperative

Secondary

Measure	Time frame
Change in corneal thickness as measured by the Pentacam HR	retrospective analysis from preoperatively to 2-14 months postoperatively
Change in visual acuity (VA)	retrospective analysis from preoperatively to 2-14 months postoperatively
Evaluation of pre-existing ocular pathology or/and ocular surgery as potential factors involved in treatment outcome	retrospective analysis from preoperatively to 2-14 months postoperatively

Countries

Germany

Outcome results