Major Depressive Disorder
Conditions
Keywords
Physical exercise, Biomarkers, Neuroprotection, ergospirometry, Major Depressive Disorder
Brief summary
Depression is a disorder that causes major harm to physical health and social life. It induces isolation, reduced physical and work capacity and increasing the risk of death. In contrast, exercise helps to maintain quality of life, also inducing improvement of cognitive functions, stimulation of brain plasticity and resilience, in addition to promoting self-esteem and social interaction. The precise mechanisms by which exercise improves symptoms of depression are not fully clear, but it is probably multifactorial. In this project, the investigators aim to investigate variables that provide additional information about biomarkers involved in the pathophysiology of depression and therapeutic response to exercise. The investigators expect to find changes in biomarkers associated with potential mechanisms of neuroprotection (cytokines, markers of oxidative stress, Brain-derived neurotrophic factor (BDNF), cortisol) after exercise program and the role in the therapeutics of depression. To evaluate functional assessment indices will be used ergospirometry, a test that determines the respiratory, cardiovascular and metabolic activity. Overall, this project will help to investigate alternative adjunctive treatments for depression and their associated biomarkers with response.
Interventions
OTHERPhysical Exercise
physical exercise
Sponsors
Fundação de Amparo à Pesquisa do Estado de São Paulo
University of Sao Paulo General Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 55 Years
Healthy volunteers
No
Inclusion criteria
* Major Depression Disorder According Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) criteria * Score higher or equal 18 in Hamilton Depression Rating Scale * Age between 18 and 55 years old
Exclusion criteria
* Unstable Clinical Diseases * Patients Unable to make Physical Exercises * Present frequencies below 90% attendance in the program aerobic fitness
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Physical exercise evaluation | One year | Evaluate the physical exercise influence on the symptoms, according to HAM-D criteria, at the end of training program. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Biomarkers level comparison | One year | To compare possible levels of cytokines, before and after controled physical exercise. |
Countries
Brazil
Outcome results
None listed