Severe Brain Injury
Conditions
Keywords
brain-injury, extubation
Brief summary
Severe brain-injured patients require prolonged mechanical ventilation. Weaning these patients from mechanical ventilation is challenging. During neurologic recovery, brain injured patients usually present satisfactory respiratory autonomy. However, the exact timing of extubation is unknown and is frequently delayed because of potential inhalation. To date, there are no clinical signs available in the current literature that can help the attending physician in the decision-making process of extubation in brain-injured-patients
Interventions
A code will be applied to each patient included. Medical data such as demography, ISS, clinical exam at time of extubation, extubation failure, tracheotomy, will be collected during ICU stay.
Sponsors
Nantes University Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
15 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* Patients with brain-injury (traumatic brain injury, subarachnoid haemorrhage, stroke, intracerebral hemorrhage, brain tumour) requiring ≥ 48 hours of mechanical ventilation after admission
Exclusion criteria
* Pregnant women * Patient consent withdrawal
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Extubation failure | In the 48 hours following extubation | Extubation failure is regarded as the need of intubation in the 48 hours following extubation Establish clinial signs before extubation that can predict extubation failure Realization of a systematic clinical examination by the attending physician before performing extubation in severe brain-injured patients |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Impact of extubation failure | Median 14 days after Intensive Care Unit (ICU) admission | Impact of extubation failure on * Duration of mechanical ventilation * Length of ICU stay * Mortality Describing reasons |
Countries
France
Outcome results
None listed