Lung Cancer
Conditions
Keywords
γδ T Cell, non small lung cancer, Without EGFR Mutation
Brief summary
In this study, effects of γδT cells on human non small lung cancer ( without EGFR mutation) in combination with tumor reducing surgery, for example cryosurgery going to be investigated.
Detailed description
Non small lung cancer will be removed using tumor reducing surgery such as cryosurgery. PBMC of the patient will be separated from peripheral blood. After making them potential cancer killer γδ T Cell and DC-CIK, they will be infused to the patients as immunotherapy.
Interventions
BIOLOGICALDC-CIK
DC-CIK cells will be used against tumor cells.
BIOLOGICALγδ T Cell
γδ T cells will be used against non small lung tumor.
BIOLOGICALγδ T/DC-CIK cells
γδ T/DC-CIK cells will be used against lung tumor.
Sponsors
Jinan University Guangzhou
Fuda Cancer Hospital, Guangzhou
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
1. Age:18-75 2. Karnofsky performance status \>50 3. Diagnosis with non small lung tumors based on histology or the current accepted radiological measures. 4. Classification tumor,nodes,metastasis-classification(TNM) stage: Ⅱ,Ⅲ,Ⅳ Will receive cryosurgery, gd Tcells/ DC-CIK. 5. Life expectancy: Greater than 3 months 6. Ability to understand the study protocol and a willingness to sign a written informed consent document
Exclusion criteria
1. Patients with other kinds of cancer 2. History of coagulation disorders or anemia 3. Patients with heart disease and diabetes
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduced size of the tumor. | Up to one year |
Countries
China
Outcome results
None listed