Cerebral Infarction, Migraine, Right-to-left Shunt
Conditions
Keywords
right-to-left shunt, contrast-enhanced transcranial Doppler, migraine, silent cerebral infarction
Brief summary
The purpose of the study is to evaluate the prevalence and extent of right-to-left shunt (RLS) in Chinese migraineurs, and the morbidity of silent cerebral infarction in migraineurs.
Detailed description
This is a prospective multicenter study of Chinese population. Participants (normal individuals without migraine and migraineurs) are included after standardized diagnostic procedures (TCD and c-TCD). For migraineurs with large RLS further examinations (c-TTE and brain MRI) are required. Up to 10 study sites nationwide will be needed to recruit the planned participant population during a 1-year period. The information of each participants will be registered, including basic facts, the longitudinal headache history, frequency, location, quality, intensity, duration, accompanied symptoms, precipitating and exacerbating factors, with or without aura, MIDAS and HIT-6 questionnaire.
Interventions
None listed
Sponsors
Yingqi Xing
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
16 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* For group 1: Normal healthy individual without migraine. * For group 2: Clinical history of migraine diagnosed by a neurologist according to the International Classification of Headache Disorders.
Exclusion criteria
* Subjects with stenotic intracranial or extracranial arteries or intracranial abnormalities diagnosed with TCD.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| contrast-enhanced transcranial Doppler | 1 year |
Secondary
| Measure | Time frame |
|---|---|
| brain MRI | 1 year |
Countries
China
Outcome results
None listed