Acute Kidney Injury
Conditions
Keywords
Acute Kidney Injury Requiring Continuous Renal Replacement Therapy
Brief summary
The purpose of this study is to study the effect of anticoagulation in immune response with Acute Kidney Injury (AKI) undergoing Continuous Renal Replacement Therapy (CRRT).
Interventions
CRRT with anticoagulant : regional citrate anticoagulation Filter : AQUAMAX™ (Edwards Lifesciences)
PROCEDUREContinuous renal replacement therapy with no anticoagulation or heparin
CRRT with any anticoagulant : no anticoagulation or heparin Filter : AQUAMAX™ (Edwards Lifesciences)
Sponsors
Chulalongkorn University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* Systemic inflammatory response syndrome; SIRS \> or = 2 meets definition * Patients with acute kidney injury in the intensive care ward. * Requiring continuous renal replacement therapy.
Exclusion criteria
* Pregnancy * Cirrhosis * End stage renal disease * HIV infection * Serum creatinine in male \> 2 mg/dl and female \> 1.5 mg/dl * Bleeding
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Functions of inflammatory cells | 24 hours | CD11b expression on PMN and HLA-DR expression on monocyte |
| Regulation of inflammatory reactions and and opsonization in microorganisms | 24 hours | C3a and C5a |
| Activity of acute phase protein during acute inflammation | 24 hours | PAI-1 |
Secondary
| Measure | Time frame |
|---|---|
| survival rate | 28 days |
| length of ICU stay | 28 days |
Countries
Thailand
Outcome results
None listed