Autism Spectrum Disorder, Bipolar Disorder
Conditions
Keywords
Autism Spectrum Disorder, Bipolar Disorder, Emotions
Brief summary
The objective of this study is to identify the specific characteristics of Autism Spectrum Disorder (ASD) in emotional response profiles and shared with Bipolar Disorder (BD) characteristics.
Interventions
None listed
Sponsors
University Hospital, Tours
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* For all participants: * Age between 18 and 50 years * Normal vision (or corrected) * Absence of neurological disorder (epilepsy , head trauma, ... ) * Ability to understand information about the protocol * Informed and signed consent * normal mood (euthymia) * normal or high intelligence * Subjects with ASD: * Subjects with an autism spectrum disorder according to the DSM-5 * The diagnosis is confirmed by diagnostic interviews: ADI- R (Autism Diagnostic Interview-Revised) and / or ADOS (Autism Diagnostic Observation Schedule ) . * Subjects with bipolar disorder: * Diagnosis of bipolar disorder according to DSM-IV-TR or DSM -5 * The diagnosis is confirmed by the MINI 6.0 (The Mini-International Neuropsychiatric Interview) . * Healthy volunteers: * Inclusion after checking the national register of healthy volunteers * No history of disease of the central nervous system or psychiatric disorder * No family history of ASD or BD in the first degree * Lack of psychotropic medication or current cardiotropic * Lack of psychiatric disorder on Axis I MINI 6.0 * AQ Score \< 32
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Physiological emotional response during emotion elicitation in a laboratory session (Pupil size measured by eye tracking, heart rate, electrodermal response, breath rate) during emotion elicitation in a laboratory session | average 1 hour |
Secondary
| Measure | Time frame |
|---|---|
| Subjective emotional response during emotion elicitation in a laboratory session | average 1 hour |
| Facial emotional response during emotion elicitation in a laboratory session | average 1 hour |
| Experience sampling method in real life during a week (emotions, activities, social context, burden) | within the first 7 days after inclusion |
| Physiological emotional response in real life (heart rate, electrodermal response, breath rate, actimetry) | within the first 24h approx. after inclusion |
Countries
France
Contacts
PRINCIPAL_INVESTIGATORFrédérique BONNET- BRILHAULT, Pr
University Center of Child and Adolescent Psychiatry, University Hospital of Tours
PRINCIPAL_INVESTIGATORWissam EL-HAGE, Pr
University Psychiatric Clinic, University Hospital of Tours
PRINCIPAL_INVESTIGATORValérie GISSOT, MD-PHD
Clinical Investigation Center, INSERM 14 15, University Hospital of Tours
STUDY_DIRECTORMathieu LEMAIRE, MD-PHD
University Center of Child and Adolescent Psychiatry, University Hospital of Tours
Outcome results
None listed