Serological Evaluation of 77A/G and 11A/12A Gene of MMP-13 in Periodontitis Affected and Healthy Individuals

A Serological Evaluation of 77A/G and 11A/12A Associated Gene Polymorphisms of MMP-13 in Periodontitis Affected and Healthy Individuals

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02423304

Acronym

SEGPPAH

Enrollment

100

Registered

2015-04-22

Start date

2015-05-31

Completion date

2016-06-30

Last updated

2015-04-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Generalized Adult Periodontitis

Brief summary

50 periodontitis 50 healthy individuals serological evaluation will done to see association of 77A/G AND 11A/12A gene polymorphisms of MMP-13

Detailed description

* The study will be conducted on 100 individuals * 50 chronic periodontitis and 50 healthy individuals will be recruited from the Out Patient Department of Periodontics in the study. * An informed consent will be obtained from patients who wish to participate in the study. * Patients will be categorized by Periodontal Disease Index (PDI) by P. Ramfjord(1959) * After clinical examination, blood samples will be collected and assessed for MMP 13 Gene Polymorphisms. * Subjects will be selected according to the study criteria and divided into two groups (50 each). 1. Test group 2. Control group

Interventions

GENETICblood samples collected from all patients

blood samples collected from brachial pluxes

Study design

Observational model

COHORT

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

30 Years to 55 Years

Healthy volunteers

Yes

Inclusion criteria

• Test group 1. Patients with chronic periodontitis classified according to American Academy of Periodontology ( AAP) 1999 2. Subjects aged between 30-55 years * Control group Systemically and periodontally healthy individuals of same age group

Exclusion criteria

1. Present and past Smokers 2. Presence of any systemic diseases. 3. Oral diseases other than Periodontitis 4. With a previous history of periodontal treatment in the past 6 months and subjects under any medications. 5. Family history of any diagnosed genetic disorders.

Design outcomes

Primary

Measure	Time frame	Description
to evaluate the association of 77A/G AND 11A/12A gene polymorphism of mmp-13 in periodontitis effected and healthy individuals	6 months	collect DNA samples from serum and evaluate for gene polymorphism

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026