Transfusion Reaction
Conditions
Brief summary
The aim of the proposed project is to perform a clinical study in which volunteers will receive autologous blood transfusions in DEHP-free blood bags.
Interventions
BIOLOGICALAutologous blood transfusion
Volunteers make a blood donation and after 36 days of storage this blood is re-infused in the same volunteers.
Sponsors
Centre Hospitalier Universitaire Vaudois
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
MALE
Age
20 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* Have to fill the swiss blood donation formulary
Exclusion criteria
* Anemia * Cardiovascular disease * Neurologic disease * Not performed a blood donation for 5 weeks ago the start of the study. * Immunological disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Measurement of blood parameters profile, iron metabolism and genomic compounds | 1 month | Blood profiling such as measurement of concentration of different blood cells and hemoglobin will be measured up to 15 days after blood-reinfusion. Concentration of free-iron, ferritin and hepcidin will be measured in plasma and serum up to 15 days after blood re-infusion. Concentration of circulating microRNAs will be measured in plasma also up to 15 days after blood re-infusion. All measures are compared. |
Countries
Switzerland
Outcome results
None listed