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Stunting Prevention Project in Thatta and Sujawal Districts, Sindh Province, Pakistan

Effectiveness of Food/Nutrient Based Interventions to Prevent Stunting Among Children Under Five in Thatta and Sujawal Districts, Sindh Province, Pakistan

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT02422953
Enrollment
4020
Registered
2015-04-22
Start date
2014-08-31
Completion date
2018-09-30
Last updated
2019-11-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Malnutrition

Keywords

Stunting, Wasting, Underweight

Brief summary

Widespread food insecurity and malnutrition are largely the main impairing factors for human capital development in Pakistan. Rates of chronic malnutrition are very high, and acute malnutrition is critical: 44% of children under five are stunted and nationwide global acute malnutrition (GAM) rates amongst children under five exceed the WHO critical threshold of 15%. Nutritional status trends also show a deteriorating situation since 1994, when stunting rates were at 36%. This study evaluates the effectiveness of food based interventions to prevent stunting among children under-five years with focus on window of opportunity (1000 days from conception to 2 years) for addressing stunting. Pregnant women, lactating mothers and children 6-59 months will receive supplements on monthly basis in intervention areas, while participants in control areas will receive routine public health services available in the study area.

Detailed description

Children under two are consuming less than half of their daily energy requirements (560 kcal) and lower than recommended levels of micronutrients (one-third of reference nutrient intake for Iron and one-half for Zinc). Overall, less than 4% of children were receiving an acceptable, diverse diet. Food security and nutrition situation in Sindh province is even more dramatic. According to the National Nutrition Survey, 2011, GAM prevalence exceeds 18% while anemia levels amongst children under five reached the alarming level of 72.5%. With this high level of poverty and food insecurity, a food based approach to prevent stunting, together with non- food based approaches is needed. Therefore, Division of Women and Child Health, Aga Khan University proposes a research study for stronger evidence base on the effectiveness of preventive food/nutrient based interventions on reduction of stunting and developing viable programmes on nutrition under real operational conditions. The effectiveness of the project will be measured in terms of the impact of the proposed interventions on the stunting and micronutrient deficiency prevalences in the target group (children and mothers). Given the conditions of project implementation, a quasi-experimental double difference design would be appropriate to assess the impact of the intervention. We propose to compare the intervention and non-intervention (control) groups before (first difference) and after the intervention (second difference). Then, the operational implementation of the research comprises a baseline and end line surveys. In addition, a nested cluster randomized controlled trial will be implemented to track the evolution of key variables related to the quality of intervention delivery and intermediate nutrition outcomes. The control clusters will receive routine public and private health services available in the area. To achieve its purpose and objectives the project design includes core interventions such as complementary feeding using food/nutrient based supplements along with behavior change communication, complemented with other non-food interventions. Using a preventative (blanket) approach, three types of food/nutrient supplements (Wawamum, MNP & WSB) are considered as part of the interventions.

Interventions

DIETARY_SUPPLEMENTWheat Soya Blend (WSB)

A monthly ration of 5 Kg of Wheat Soya Blend (WSB) will be given to pregnant women every month during pregnancy and lactating mothers for six months after giving birth

DIETARY_SUPPLEMENTWawa Mum

Children 6-23 months of age will receive a daily ration of 50 gram of Wawa Mum during study period

DIETARY_SUPPLEMENTMicronutrient Powders (MNP)

Children 24-59 months of age will receive a sachet of Micronutrient Powders (MNP) in alternate days

BEHAVIORALBehavior change and preventive health massages

Behavior change and preventive health massages will be delivered by lady health workers (LHWs) during monthly visits and in group meetings

Sponsors

United Nations World Food Programme (WFP)
CollaboratorOTHER
Pakistan Ministry of Health
CollaboratorOTHER_GOV
Aga Khan University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
6 Months to 59 Months
Healthy volunteers
Yes

Inclusion criteria

* All pregnant women * All lactating mothers (upto 6 months) * All children 6-23 months of age * All children 24-59 months of age

Exclusion criteria

* Refuse to participate in the study * Having severe chronic disease

Design outcomes

Primary

MeasureTime frameDescription
Stunting-reduction in stunted children in intervention group2 YearsTo calculate HAZ scores the 2006 WHO growth reference will be used

Secondary

MeasureTime frameDescription
Mean change in weight-for-height z-score (WHZ)2 YearsTo calculate WHZ scores the 2006 WHO growth reference will be used
Mean change in weight-for-age z-score (WAZ)2 YearsTo calculate WAZ scores the 2006 WHO growth reference will be used
Improvement in infant and young child feeding (IYCF) indicators2 YearsMonthly data collection on IYCF practices
Linear growth velocity (HAZ increment/month)2 YearsTo calculate HAZ score the 2006 WHO growth reference will be used
Mean hemoglobin concentration in children 6-59 months of age2 YearsHemocue will be used to measure Hb concentration
Prevalence of childhood anemia (Hb concentration<11g/dL) in children 6-59 months of age2 YearsHb spot testing will be conducted
Pregnancy out come2 YearsReduction in low birth weight in newborns
Prevalence of maternal anemia (Hb concentration<12g/dL)2 YearsHb spot testing will be conducted
Impact on maternal BMI2 YearsThe change in BMI z-score weight and height will be combined to report BMI in kg/m\^2
Impact on vitamin A status in children at 24 months2 YearsThe change in Vitamin A status (µmol/L) in children at 24 months of age
Impact on vitamin D status in children at 24 months2 YearsThe change in vitamin D status (ng/mL) in children at 24 months of age
Impact on Zinc status in children at 24 months2 YearsThe change in Zinc status (µg/dL) in children at 24 months of age
Impact on Ferritin status in children at 24 months2 YearsThe change in Ferritin status (ng/mL) in children at 24 months of age
Mean hemoglobin concentration in mothers2 YearsHemocue will be used to measure Hb concentration

Countries

Pakistan

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 27, 2026