Healthy
Conditions
Brief summary
During this project the effect of 3 different bran-based dietary platforms on the fermentation on a readily fermentable substrate will be investigated using stable isotope techniques.
Interventions
DIETARY_SUPPLEMENTUnmodified wheat bran
DIETARY_SUPPLEMENTWheat bran with reduced particle size
DIETARY_SUPPLEMENTDestarched pericarp-enriched wheat bran
DIETARY_SUPPLEMENTNo wheat bran fraction
Sponsors
KU Leuven
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy * Aged between 18 and 65 years * BMI between 18 and 27 kg/m² * Stable eating pattern (3 meals/day on at least 5 days/week)
Exclusion criteria
* Use of antibiotics in the month preceding the study * Abdominal surgery (except from appendectomy) * Use of medication that affects the gastrointestinal tract during the last 2 weeks prior to the study including spasmolytics, anti-diarrhoea medication, anti-constipation medication * Use of pre- or probiotic supplements in the month preceding the study * Chronic gastrointestinal diseases, such as inflammatory bowel disease (Crohn's disease, ulcerative colitis), irritable bowel disease… * Pregnancy or lactation * Blood donation in the last 3 months * Abnormal Hb-level (Standard range between 14 and 18 g/dL for men and between 12 and 16 g/dL for women) * Participation in clinical studies involving radiation exposure in the past year
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quantification of acetate, propionate and butyrate production in the colon after consumption of each bran-based dietary platform | 2 years |
Secondary
| Measure | Time frame |
|---|---|
| Estimation of the site of fermentation of a readily fermentable carbohydrate in the presence of different bran-based dietary platforms | 2 years |
Countries
Belgium
Outcome results
None listed