Effectiveness of Gum Chewing on Ileus in Chinese Colorectal Patients Underwent Laparoscopic Colorectal Surgery

Effectiveness of Gum Chewing on Reduction of Postoperative Paralytic Ileus for Chinese Colorectal Cancer Patients Underwent Laparoscopic Colorectal Surgery and Enhanced Recovery Program

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02419586

Enrollment

Registered

2015-04-17

Start date

2015-01-31

Completion date

2016-06-30

Last updated

2018-06-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colorectal Cancer

Brief summary

Gum chewing group will have less ileus and early resume of bowel motion than control group.

Detailed description

The standardize surgical techniques, less used of epidural analgesia, early ambulation and used of naso-gastric tube for decompression are aimed to reduce the paralytic ileus after abdominal surgery . Most Western studies have examined and found that gum chewing are able to prevent postoperative ileus or promotes early bowel function after abdominal surgery.

Interventions

OTHERbubble gum

Chewing gum group patients performing gum chewing on postoperative day 1 at three times daily for 30 minutes after operation and until discharged.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients with newly diagnosed colorectal cancer undergoing laparoscopic resection in in Queen Mary Hospital * At least 18 years * Speak Cantonese * Able to follow study protocol and chewing gum study

Exclusion criteria

* Cognitive disability * Requirement of epidural analgesia * Requirement of intensive care unit/ High dependency unit care postoperatively * Inability to chew * Presence of procedure other than colorectal resection * Non Chinese

Design outcomes

Primary

Measure	Time frame	Description
Time to first flatus	from postoperative day 0 till an expected average of day 7	Time to passage of flatus after surgery was significantly shorter in the intervention group (22 vs 39 hours, p=0.007).

Secondary

Measure	Time frame	Description
Length of stay	from postoperative day 0 till an expected average of day 7	There is no difference in length of stay between intervention group or control group
Time to first bowel movement,	from postoperative day 0 till an expected average of day 7	The first bowel motion also occurred earlier in the intervention group (22 vs 52 hours, p\<0.001)
Time to first sense of hunger	from postoperative day 0 till an expected average of day 7	Patients in the intervention group also noticed feeling of hunger earlier (17 vs 40 hours, p\<0.001).

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 1, 2026