Breast Cancer
Conditions
Keywords
γδ T Cell, breast cancer, her2-, er-, pr-
Brief summary
In this study, effects of γδT cells on human breast cancer (her2-, er-,pr-) in combination with tumor reducing surgery, for example cryosurgery going to be investigated.
Detailed description
Breast tumor will be removed using tumor reducing surgery such as cryosurgery. PBMC of the patient will be separated from peripheral blood. After making them potential cancer killer γδ T Cell and DC-CIK, they will be infused to the patients as immunotherapy.
Interventions
BIOLOGICALDC-CIK
DC-CIK cells will be used against tumor cells.
BIOLOGICALγδ T Cell
γδ T cells will be used against breast tumor.
BIOLOGICALCombination
γδ T/DC-CIK cells will be used against breast tumor.
Sponsors
Jinan University Guangzhou
Fuda Cancer Hospital, Guangzhou
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
1. Age:18-75 2. Karnofsky performance status \>50 3. Diagnosis with breast tumors based on histology or the current accepted radiological measures. 4. Classification tumor,nodes,metastasis-classification(TNM) stage: Ⅱ,Ⅲ,Ⅳ 5. Will receive cryosurgery, gd Tcells/ DC-CIK. 6. Life expectancy: Greater than 3 months 7. Ability to understand the study protocol and a willingness to sign a written informed consent document
Exclusion criteria
1. Patients with other kinds of cancer 2. History of coagulation disorders or anemia 3. Patients with heart disease and diabetes
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduced size of the tumors | Up to one year |
Countries
China
Outcome results
None listed