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Resistant Starch and Whey Protein on Energy Metabolism

Combined Effects of Dietary Supplementation With Dietary Resistant Starch (RS) and Whey Protein on Resting Energy Expenditure and Blood Sugar and Insulin Responses in Lean and Obese Men and Women

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT02418429
Enrollment
32
Registered
2015-04-16
Start date
2013-08-31
Completion date
2018-08-31
Last updated
2018-09-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Weight Loss

Keywords

fat oxidation, hunger, resistant starch, whey protein

Brief summary

Recent evidence shows that dietary supplementation with resistant starch (RS) increases fat catabolism and resting energy expenditure and decreases plasma insulin and glucose responses as well as the gut-derived hormone, glucose-dependent insulinotropic polypeptide (GIP). Consumption of whey protein has also been shown to increase energy expenditure and favorably affect gut hormones. Thus, investigators tested consumption of both RS and whey protein on energy expenditure and gut hormones in lean and obese women and men.

Detailed description

Consumed separately, resistant starch (RS) and whey protein (WP) favorably affect energy metabolism and gut hormones, as well as suppress feelings of hunger. These findings are important because release of certain gut hormones (i.e., GIP) is associated with a lower resting energy expenditure (REE) in healthy humans. Interestingly, a recent study showed that ingestion of RS reduces postprandial GIP and increases postprandial REE and fat utilization in healthy men and therefore may be an effective strategy in weight management. Thus, there is a need to replicate these findings in a healthy cohort of lean and obese women and men. The purpose of this study was to examine the effects of RS on the number of calories burned after eating a meal, as well as specific hormones that are released from the stomach and intestines following meal ingestion in healthy lean and obese women and men. Investigators used a single ingestion of a meal supplemented with or without the resistant starch and whey protein.

Interventions

OTHERwaxy maize starch

pancake test meal with waxy maize starch only

OTHERwaxy maize starch and Whey Protein

pancake test meal with waxy maize starch and whey protein

OTHERResistant Starch

pancake test meal with resistant starch only

OTHERresistant starch and whey protein

pancake test meal with resistant starch and whey protein

Sponsors

Skidmore College
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
SINGLE (Subject)

Eligibility

Sex/Gender
ALL
Age
30 Years to 65 Years
Healthy volunteers
Yes

Inclusion criteria

* overweight or lean but otherwise healthy

Exclusion criteria

* Participants will be excluded if they smoke; have experienced excessive weight loss/gain of \> ±2kg in the previous 2 months; are currently taking medications for cardiovascular or metabolic disease.

Design outcomes

Primary

MeasureTime frameDescription
Change in fat oxidation from Baseline to 180 Minutes Postprandialtime 0, 60, 120, 180 minutesindirect calorimetry of fuel utilization

Secondary

MeasureTime frameDescription
Change in gut hormones from Baseline to 180 Minutes Postprandialtime 0, 60, 120, 180 minutesgastro-entero-pancreatic hormones
Change in self-reported feelings of hunger, fullness, satiation from Baseline to 180 Minutes Postprandialtime 0, 60, 120, 180 minutesvisual analog scale of hunger, fullness and satiation

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 15, 2026