Periodontitis
Conditions
Keywords
biomarkers, renal disease, periodontitis
Brief summary
Analysis of inflammatory markers in periodontitis and patients with early and middle stage renal disease.
Detailed description
A total of 200 population is recruited, individuals are divided into four groups according to a periodontal examination and a general physical examination: healthy individuals ,periodontitis, renal disease patients with healthy periodontium, and renal disease patients wth peridontitis. Fasting blood samples and gingival crevicular fluid are collected from all individuals, and inflammatory markers are analysed for the four groups.
Interventions
None listed
Sponsors
Zhejiang University
Study design
Observational model
CASE_CROSSOVER
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
25 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
* all participants were in general good health(except renal disease) and non-smoking
Exclusion criteria
* less than 20 teeth in the dentin * hypertension * the presence of systemic disease (e.g., diabetes mellitus ,coronary heart disease, liver, or lung disease) * a history or the symptom of any other acute or chronic infections * systemic antibiotic treatment within previous 4 weeks * periodontal treatment within1 month
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Inflammatory markers analysis of the four groups | 3 months after sampling | Analysis of inflammatory biomarkers of blood and gingival crevicular fluid samples of the four groups |
Countries
China
Contacts
Primary ContactNa Zhou
Backup ContactYan Tu
Outcome results
None listed