Vitamin D Status and Immune Function

Conditions

Vitamin D Deficiency

Brief summary

The purpose of this study is to examine the relationship between Vitamin D status and immunity.

Detailed description

Vitamin D is mainly obtained from the sun and follows a seasonal pattern, with Vitamin D levels peaking in summer and reaching a trough during winter. Vitamin D deficiency is associated with impaired immunity. However, knowledge of Vitamin D deficiency with in vivo immunity is limited. This observational study aims to investigate the relationship between Vitamin D status and the in vivo immunity.

Kashi DS, Oliver SJ, Wentz LM, Roberts R, Carswell AT, Tang JCY, Jackson S, Izard RM, Allan D, Rhodes LE, Fraser WD, Greeves JP, Walsh NP.

2020-05-1028 citations

10.1007/s00394-020-02261-w

The dynamic relationships between the active and catabolic vitamin D metabolites, their ratios, and associations with PTH.

Tang JCY, Jackson S, Walsh NP, Greeves J, Fraser WD, Bioanalytical Facility team.

2019-05-0656 citations

10.1038/s41598-019-43462-6

Vitamin D insufficiency and elevated vitamin D metabolite ratios (VMR) are associated with increased risk of injuries: Results from the british army lower limb injury prevention (ALLIP) study

Jonathan Tang, Sarah Jackson, Rachel M. Izard, Samuel J. Oliver, Isabelle Piec et al. (9 authors)

Endocrine Abstracts2018-11-02

10.1530/endoabs.59.oc1.2

Interventions

OTHERIn vivo immunity model

A measure of in vivo immune function.

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 35 Years

Healthy volunteers

Yes

Inclusion criteria

* Passed medical assessment by medical doctor * Passed audio test (this is part of medical assessment) * Met physical fitness requirements

Exclusion criteria

• Medically deferred by medical doctor

Design outcomes

Primary

Measure	Time frame	Description
Vitamin D measured by liquid chromatography tandem mass spectroscopy	Up to 20 months	Circulating 25-hydroxy-vitamin D

Secondary

Measure	Time frame	Description
Immune function measured by analytic biochemistry assay	Up to 20 months	In vivo immune measure

Countries

United Kingdom

Outcome results

None listed